Brain-based immune proteins may regulate sleep
Friday - February 3, 2017 3:02 pm ,
Category : HEALTH
New York:Sleep may be regulated in part by several brain-based immune proteins, says a study that could pave the way for new therapies to treat chronic sleep disorders and sleep disturbances secondary to other diseases.
The immune proteins — collectively called inflammasome NLRP3 — recruit a sleep-inducing molecule to trigger somnolence following sleep deprivation and exposure to a bacterial toxin, showed results of the study published in the journal Brain, Behavior, and Immunity.
Animals lacking genes for this protective immune complex showed profound sleep aberrations.
“Our research points, for the first time, to the inflammasome acting as a universal sensing mechanism that regulates sleep through the release of immune molecules,” said study senior investigator Mark Zielinski from Harvard Medical School.
In a series of experiments, the scientists demonstrated that following sleep deprivation or exposure to bacteria, the inflammasome activates an inflammatory molecule called interleukin-1 beta, known to induce sleep and promote sleep intensity.
The immune proteins — collectively called inflammasome NLRP3 — recruit a sleep-inducing molecule to trigger somnolence following sleep deprivation and exposure to a bacterial toxin, showed results of the study published in the journal Brain, Behavior, and Immunity.
Animals lacking genes for this protective immune complex showed profound sleep aberrations.
“Our research points, for the first time, to the inflammasome acting as a universal sensing mechanism that regulates sleep through the release of immune molecules,” said study senior investigator Mark Zielinski from Harvard Medical School.
In a series of experiments, the scientists demonstrated that following sleep deprivation or exposure to bacteria, the inflammasome activates an inflammatory molecule called interleukin-1 beta, known to induce sleep and promote sleep intensity.
